Genetic control of natural resistance of mouse macrophages to Coxiella burnetii infection in vitro: Macrophages from restrictive strains control parasitophorous vacuole maturation

Genetic control of natural resistance of mouse macrophages to Coxiella burnetii infection in vitro: Macrophages from restrictive strains control parasitophorous vacuole maturation

Autor Zamboni, Dario Simões Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Macrophages from A/J and BALB/c mice were more susceptible to Coxiella burnetti phase II infection than were those from C57BL/6, C57BL/10, B10.A, C3H/HePas, and Swiss mice. Resistant macrophages effectively controlled the development of large replication vacuoles (LRVs), which accounted for the restriction of bacterial multiplication within the cultures. However, compared to fibroblasts, all macrophages controlled bacterial multiplication within LRVs.
Idioma Inglês
Data 2004-04-01
Publicado em Infection and Immunity. Washington: Amer Soc Microbiology, v. 72, n. 4, p. 2395-2399, 2004.
ISSN 0019-9567 (Sherpa/Romeo, fator de impacto)
Editor Amer Soc Microbiology
Extensão 2395-2399
Fonte http://dx.doi.org/10.1128/IAI.72.4.2395-2399.2004
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000220481600065
URI http://repositorio.unifesp.br/handle/11600/27685

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