FTY720 treatment prolongs skin graft survival in a completely incompatible strain combination

FTY720 treatment prolongs skin graft survival in a completely incompatible strain combination

Autor Lima, RSM Google Scholar
Nogueira-Martins, M. F. Google Scholar
Silva, H. T. Google Scholar
Pestana, JOM Google Scholar
Bueno, V Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo FTY720 has shown potent immunomodulatory activity in a variety of animal organ transplant models. However, the in vivo immunosuppressive mechanism of FTY720 is still not fully understood. It has been suggested that the marked decrease in the number of peripheral blood lymphocytes during FTY720 administration could be responsible for its immunosuppressive effects. Our aims were: (1) to study the effects of FTY720 treatment on skin graft survival using a fully mismatched strain combination and (2) to evaluate lymphocyte numbers in different sites at 5 days after skin transplant. C57BL/6 mice and BALB/c mice were the donors and recipients respectively. BALB/c mice received FTY720 (1 mg/kg/d) orally for 4 consecutive days. Drug administration started 1 day before skin transplants. A small segment of tail skin was affixed on the right dorsal side of the mouse via sutures. the administration of FTY720 (4 mg/kg) prolonged skin graft survival from 12.6 +/- 2.2 days (no treatment) to 16.6 +/- 4.2 days. the histologic findings of rejection were similar for all groups. Five days after transplant, lymphocyte numbers were significantly increased in lymph nodes compared with nontransplanted or isogenic graft mice. FTY720 decreased lymphocyte numbers only in the spleen. in conclusion, FTY720 prolonged skin graft survival in a fully mismatched strain combination when administered for 4 days (day -1 to day +2) at a dose of 1 mg/kg/d. the decreased number of lymphocytes in the spleen suggests that the spleen may be a target of FTY720 activity, during the early posttransplant period.
Idioma Inglês
Data 2004-05-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 36, n. 4, p. 1015-1017, 2004.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 1015-1017
Fonte http://dx.doi.org/10.1016/j.transproceed.2004.03.052
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000222063800078
URI http://repositorio.unifesp.br/handle/11600/27741

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