Expression of cyclooxygenases during renal allograft rejection

Expression of cyclooxygenases during renal allograft rejection

Autor Rangel, E. B. Google Scholar
Moura, L. A. Google Scholar
Franco, M. Google Scholar
Pacheco-Silva, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The aim of this work was to determine the expression of cyclooxygenases (COX-1 and COX-2) during acute human renal allograft rejection. RT-PCR and immunohistochemistry were performed. the COX-2 mRNA was more abundant than COX-1 mRNA in the group with acute rejection (P < .001). the locations of COX-1 and COX-2 protein were consistent with the literature. Expression of COX-2 immunoreactive protein was higher in interstitial cells in the group with acute rejection than in the control group (P = .04). COX-2 protein was more abundant than COX-1 protein in the group with acute rejection, including podocytes (P < .001), proximal tubular cells (P < .001), collecting duct cells (P = .003), and interstitial cells (P < .001). in conclusion, COX-2 which is up-regulated during acute human renal allograft rejection, may play a role in renal inflammation.
Idioma Inglês
Data 2004-05-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 36, n. 4, p. 838-839, 2004.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 838-839
Fonte http://dx.doi.org/10.1016/j.transproceed.2004.03.106
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000222063800013
URI http://repositorio.unifesp.br/handle/11600/27749

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