Assessment of urodynamic bladder behavior on filling with solutions representing physiological extremes of urinary osmolarity

Assessment of urodynamic bladder behavior on filling with solutions representing physiological extremes of urinary osmolarity

Autor Truzzi, Jose C. Autor UNIFESP Google Scholar
Bruschini, Homero Autor UNIFESP Google Scholar
Srougi, Miguel Autor UNIFESP Google Scholar
Ortiz, Valdemar Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE: Verify if there is any difference in sensitive and motor bladder response in the presence of solutions with different osmolarities, simulating physiological extremes of urinary osmolarity. MATERIALS AND METHODS: Thirty-three patients (24 men and 9 women) with mean age of 46.4 years (8 to 87 years) took part in this study. They were all subjected to 2 consecutive urodynamic examinations. In each exam, the vesical filling was accomplished by using a hyperosmolar (1000 mOsm/L) or hypo-osmolar (100 mOsm/L) sodium chloride solution in similar speed. The sequence in which each solution was instilled was determined by a double blind draw. The urodynamic results obtained from the infusion of both solutions were compared, regardless the sequence of administration. RESULTS: Fifteen patients (45.4%) showed detrusor hyperactivity, 12 of whom with neurological antecedents. The mean age of those with detrusor hyperactivity was 45.8 years, against 46.9 for those without hyperactivity. The infusion of the hyperosmolar/hypo-osmolar solution generated the following results, when comparing patients without vs. with detrusor hyperactivity: initial sensation of vesical filling (mL): 167.5 / 159.2 vs. 134.9 / 157.3 (p > 0.05); volume of occurrence of the first involuntary bladder contraction (mL): 163.9 / 151.9 (p > 0.05); detrusor micturition pressure (cm H2O): 24.0 / 24.4 vs. 13.8 / 27.5 (p > 0.05). CONCLUSION: The vesical filling with solutions simulating extreme urinary osmolarities, accomplished with similar speed and without previous identification, did not likewise alter the sensitive and motor urodynamic behavior in the current study.
Assunto bladder
urodynamics
hypertonic solutions
hypotonic solutions
overactive bladder
Idioma Inglês
Data 2005-12-01
Publicado em International braz j urol. Sociedade Brasileira de Urologia, v. 31, n. 6, p. 569-578, 2005.
ISSN 1677-5538 (Sherpa/Romeo)
Editor Sociedade Brasileira de Urologia
Extensão 569-578
Fonte http://dx.doi.org/10.1590/S1677-55382005000600011
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1677-55382005000600011 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/2829

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