A new nomogram to predict pathologic outcome following radical prostatectomy

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dc.contributor.author Crippa, Alexandre [UNIFESP]
dc.contributor.author Srougi, Miguel [UNIFESP]
dc.contributor.author Dall'Oglio, Marcos Francisco [UNIFESP]
dc.contributor.author Antunes, Alberto A. [UNIFESP]
dc.contributor.author Leite, Kátia Ramos Moreira [UNIFESP]
dc.contributor.author Nesrallah, Luciano J. [UNIFESP]
dc.contributor.author Ortiz, Valdemar [UNIFESP]
dc.date.accessioned 2015-06-14T13:32:02Z
dc.date.available 2015-06-14T13:32:02Z
dc.date.issued 2006-04-01
dc.identifier http://dx.doi.org/10.1590/S1677-55382006000200005
dc.identifier.citation International braz j urol. Sociedade Brasileira de Urologia, v. 32, n. 2, p. 155-164, 2006.
dc.identifier.issn 1677-5538
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/2990
dc.description.abstract OBJECTIVE: To develop a preoperative nomogram to predict pathologic outcome in patients submitted to radical prostatectomy for clinical localized prostate cancer. MATERIALS AND METHODS: Nine hundred and sixty patients with clinical stage T1 and T2 prostate cancer were evaluated following radical prostatectomy, and 898 were included in the study. Following a multivariate analysis, nomograms were developed incorporating serum PSA, biopsy Gleason score, and percentage of positive biopsy cores in order to predict the risks of extraprostatic tumor extension, and seminal vesicle involvement. RESULTS: In univariate analysis there was a significant association between percentage of positive biopsy cores (p < 0.001), serum PSA (p = 0.001) and biopsy Gleason score (p < 0.001) with extraprostatic tumor extension. A similar pathologic outcome was seen among tumors with Gleason score 7, and Gleason score 8 to 10. In multivariate analysis, the 3 preoperative variables showed independent significance to predict tumor extension. This allowed the development of nomogram-1 (using Gleason scores in 3 categories - 2 to 6, 7 and 8 to 10) and nomogram-2 (using Gleason scores in 2 categories - 2 to 6 and 7 to 10) to predict disease extension based on these 3 parameters. In the validation analysis, 87% and 91.1% of the time the nomograms-1 and 2, correctly predicted the probability of a pathological stage to within 10% respectively. CONCLUSION: Incorporating percent of positive biopsy cores to a nomogram that includes preoperative serum PSA and biopsy Gleason score, can accurately predict the presence of extraprostatic disease extension in patients with clinical localized prostate cancer. en
dc.format.extent 155-164
dc.language.iso eng
dc.publisher Sociedade Brasileira de Urologia
dc.relation.ispartof International braz j urol
dc.rights Acesso aberto
dc.subject prostatic neoplasms en
dc.subject neoplasm staging en
dc.subject nomograms en
dc.subject prostate-specific antigen en
dc.subject needle biopsy en
dc.title A new nomogram to predict pathologic outcome following radical prostatectomy en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Federal University of São Paulo Division of Urology
dc.description.affiliationUnifesp UNIFESP, Division of Urology
dc.identifier.file S1677-55382006000200005.pdf
dc.identifier.scielo S1677-55382006000200005
dc.identifier.doi 10.1590/S1677-55382006000200005
dc.description.source SciELO

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