Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects

Immune cellular parameters of leprosy and human immunodeficiency virus-1 co-infected subjects

Autor Carvalho, Karina I. Autor UNIFESP Google Scholar
Maeda, Solange Autor UNIFESP Google Scholar
Marti, Luciana Google Scholar
Yamashita, Jane Autor UNIFESP Google Scholar
Haslett, Patrick A. J. Google Scholar
Kallas, Esper Georges Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Miami
Albert Einstein Res Inst
Resumo Leprosy and human immunodeficiency virus-1 (HIV-1) are examples of human infections where interactions between the pathogen and the host cellular immunity determine the clinical manifestations of disease. Hence, a significant immunopathological interaction between HIV-1 and leprosy might be expected. in the present study we explored several aspects of cellular immunity in patients co-infected with HIV-1 and Mycobacterium leprae. Twenty-eight individuals were studied, comprising four groups: healthy controls, HIV-1 and M. leprae co-infection, HIV-1 mono-infection, and M. leprae mono-infection. Subjects in the mono-infection and co-infection groups were matched as far as possible for bacillary load and HIV disease status, as appropriate. Peripheral blood mononuclear cells (PBMC) were analysed using six- and seven-colour flow cytometry to evaluate T-cell subpopulations and their activation status, dendritic cell (DC) distribution phenotypes and expression of IL-4 by T cells. the co-infected group exhibited lower CD4 : CD8 ratios, higher levels of CD8(+) T-cell activation, increased V delta 1 : V delta 2 T cell ratios and decreased percentages of plasmacytoid DC, compared with HIV-1 mono-infected subjects. Across infected groups, IL-4 production by CD4(+) T lymphocytes was positively correlated with the percentage of effector memory CD4(+) T cells, suggesting antigenically driven differentiation of this population of T cells in both HIV-1 and M. leprae infections. Co-infection with M. leprae may exacerbate the immunopathology of HIV-1 disease. A T helper 2 (Th2) bias in the CD4(+) T-cell response was evident in both HIV-1 infection and leprosy, but no additive effect was apparent in co-infected patients.
Assunto HIV
leprosy
co-infection
lymphocytes
IL-4
Idioma Inglês
Data 2008-06-01
Publicado em Immunology. Malden: Wiley-Blackwell, v. 124, n. 2, p. 206-214, 2008.
ISSN 0019-2805 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 206-214
Fonte http://dx.doi.org/10.1111/j.1365-2567.2007.02756.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000255924900007
URI http://repositorio.unifesp.br/handle/11600/30674

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