Immunologic features of HIV-1-infected women on HAART at delivery

Immunologic features of HIV-1-infected women on HAART at delivery

Autor Ono, Erika Autor UNIFESP Google Scholar
Dos Santos, Amelia Miyashiro Autor UNIFESP Google Scholar
Machado, Daisy Maria Autor UNIFESP Google Scholar
Succi, Regina Célia de Menezes Autor UNIFESP Google Scholar
Amed, Abes Mahmed Autor UNIFESP Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Kallas, Esper Georges Autor UNIFESP Google Scholar
De Moraes-Pinto, Maria Isabel Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: the conjoint effect of HIV infection and pregnancy on the immune system of women submitted to the prophylactic antiretroviral therapy presently recommended is still poorly understood.Methods: We evaluated 44 HIV-infected women (HIV) and 45 HIV-negative women (CT) at parturition and we compared them to 20 healthy nonpregnant women (NP). Immunophenotyping of lymphocytes was done by four-color flow cytometry.Results: All HIV-infected women received HAART during pregnancy and 56.8% had viral load <50 copies/mL at delivery. CD4+T cells/mm(3) were lower in HIV (447) than CT (593) and NP (738) (P < 0.05). CD8+T cells/mm(3) were higher in HIV (799) than CT (384) and NP (395) (P < 0.05). NK cells/mm(3) were lower in HIV (146) than in CT (253) and NP (198) (P < 0.05). CD38 expression on CD4+T and on CD8+T cells was higher in HIV (CD4:12.1; CD8:14.9) than in CT(CD4:9.2; CD8:10.2) and NP(CD4:8.6; CD8:6.0) (P < 0.05). However, CD56 expression on CD8+T cells (a marker of cytolytic effector function) was lower in HIV(7%) than in CT(12%) and NP(9%) (P < 0.05).Conclusions: Even with low levels of viremia, HIV-infected women at delivery showed a different immunologic profile from both healthy non-HIV-infected women in the puerperium and nonpregnant women, with lower CD4+T and higher CD8+T cells, high levels of CD38 expression, but low CD56 expression on CD8+T cells and low NK cell numbers. (C) 2008 Clinical Cytometry Society.
Assunto immunophenotyping
HAART
gestation
HIV
Idioma Inglês
Data 2008-07-01
Publicado em Cytometry Part B-clinical Cytometry. Malden: Wiley-Blackwell, v. 74B, n. 4, p. 236-243, 2008.
ISSN 1552-4949 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 236-243
Fonte http://dx.doi.org/10.1002/cyto.b.20418
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000256870500005
URI http://repositorio.unifesp.br/handle/11600/30739

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