The catechol-O-methyltransferase (COMT) gene polymorphism and prevalence of uterine fibroids

The catechol-O-methyltransferase (COMT) gene polymorphism and prevalence of uterine fibroids

Autor Oliveira, Emerson de Autor UNIFESP Google Scholar
Castro, Rodrigo de Aquino Autor UNIFESP Google Scholar
Vieira Gomes, Mariano Tamura Autor UNIFESP Google Scholar
Cotrim Guerreiro da Silva, Ismael Dale Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Lima, Geraldo Rodrigues de Autor UNIFESP Google Scholar
Ferreira Sartori, Marair Gracio Autor UNIFESP Google Scholar
Batista Castello Girao, Manoel Joao Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: To assess the possible association between the catechol-O-methyltransferase (COMT) polymorphism and uterine fibroids in Brazilian women.Design: Case-control study.Patient(s): One hundred twenty-four premenopausal women with fibroids, and 193 postmenopausal controls not presenting the disease.Intervention(s): the subjects were classified as white or non-white (black and mulatto), and COMT genotypes were determined. DNA was extracted from the uterus of cases and from peripheral blood of controls and submitted to polymerase chain reaction (PCR) and agarose gel electrophoresis.Main outcome measure(s): the presence of the COMT polymorphism was recorded for all patients, and the frequency and distribution among cases and controls were compared according to race. Binomial log regression models were used to estimate odds-ratios (OR) for uterine volumes of <290 cm(3) (small fibroids) vs. those >290 cm(3) (large fibroids). Potential confounding variables (age, race and parity) were added to the model.Results: Genotypes positive for the COMT polymorphism (heterozygous or mutant homozygous) were found in 45% of white and 28.9% of non-white women (p =.013) and the polymorphic allele frequencies in these groups were 27.2% and 16.3%, respectively (p=.006). However, there were no clear differences between patients and controls within the white subgroup with regard to the presence of COMT polymorphism-containing genotypes (41.5% vs. 46.0%, respectively) (p =.60), or for the polymorphic allele frequency (26.8% vs. 27.3%, respectively) (p =.92). for non-white women, there were also no differences between cases and controls for the frequency of polymorphic genotypes (28.9% vs. 28.9%, respectively) (p =.995), or for the polymorphic allele frequency (17.8 vs. 14.5, respectively) (p =.565).Estimated OR for small or large fibroids in association with the polymorphic allele revealed a positive association between the allele with lower activity and large fibroids (vs. small) (OR = 3.3; 95% confidence interval [CI] = 1.31-8.46). the adjusted OR was 4.35 (95% confidence interval [CI] = 1.58-11.9).Conclusions: the catechol-O-methyltransferase polymorphism is a risk factor for the development of large uterine fibroids in Brazilian women suffering from fibroids. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Assunto Uterine fibroids
Uterine leiomyoma
Risk factors
Catechol-O-methyltransferase
Polymorphism
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 03/04533-1
Data 2008-07-01
Publicado em Maturitas. Clare: Elsevier B.V., v. 60, n. 3-4, p. 235-238, 2008.
ISSN 0378-5122 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 235-238
Fonte http://dx.doi.org/10.1016/j.maturitas.2008.07.001
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000260640900007
URI http://repositorio.unifesp.br/handle/11600/30741

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