Molecular assessment of invasive Streptococcus pneumoniae serotype 1 in Brazil: evidence of clonal replacement

Molecular assessment of invasive Streptococcus pneumoniae serotype 1 in Brazil: evidence of clonal replacement

Autor Chou, Ana-Carolina Google Scholar
Andrade, Soraya Sgambatti Autor UNIFESP Google Scholar
Almeida, Samanta Cristine G. Google Scholar
Zanella, Rosemeire Cobo Google Scholar
Andrade, Ana-Lucia Google Scholar
Cunto Brandileone, Maria-Cristina de Google Scholar
Instituição Adolfo Lutz Inst
Universidade Federal de São Paulo (UNIFESP)
Resumo In Brazil, serotype 1 Streptococcus pneumoniae is one of the most prevalent causes of severe infection. This study investigated the genetic relatedness of 134 serotype 1 isolates obtained from invasive diseases during the period 1977-2005. Molecular typing by PFGE revealed two major lineages using visual inspection and computer analysis. Type A comprised 94 isolates (70.2%) with four subtypes, whereas type B comprised 40 isolates (29.8%) with eight subtypes. Subtype A3, the most frequent genotype, accounting for 65% of the total isolates, was identified as a representative of clone Sweden(1)-40 (ST304). Type B was predominant in the period 1977-1988. in contrast, an increase in the type A lineage was detected from 1990 in Brazil, significantly associated with isolates recovered from pneumonia cases and from young patients. This study clearly established a temporal switch between two lineages of S. pneumoniae serotype 1 in Brazil, with a wide dispersion of clone Sweden(1)-40 in recent years.
Idioma Inglês
Data 2008-07-01
Publicado em Journal of Medical Microbiology. Reading: Soc General Microbiology, v. 57, n. 7, p. 839-844, 2008.
ISSN 0022-2615 (Sherpa/Romeo, fator de impacto)
Editor Soc General Microbiology
Extensão 839-844
Fonte http://dx.doi.org/10.1099/jmm.0.47612-0
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000257520100007
URI http://repositorio.unifesp.br/handle/11600/30746

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