Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function

Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function

Autor Fernandes, Fernanda B. Autor UNIFESP Google Scholar
Plavnik, Frida L. Autor UNIFESP Google Scholar
Teixeira, Andressa M. S. Autor UNIFESP Google Scholar
Christofalo, Dejaldo M. J. Autor UNIFESP Google Scholar
Ajzen, Sergio A. Autor UNIFESP Google Scholar
Higa, Elisa M. S. Autor UNIFESP Google Scholar
Ronchi, Fernanda A. Autor UNIFESP Google Scholar
Sesso, Ricardo C. C. Autor UNIFESP Google Scholar
Casarini, Dulce E. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The aim of this study was to investigate the association between urinary 90 kDa N-domain Angiotensin I-converting enzyme (ACE) form with C-reactive protein (CRP) and homocysteine plasma levels (Hcy), urinary nitric oxide (NOu), and endothelial function (EF) in normotensive subjects. Forty healthy subjects were evaluated through brachial Doppler US to test the response to reactive hyperemia and a panel of blood tests to determine CRP and Hcy levels, NOu, and urinary ACE. They were divided into groups according to the presence (ACE90+) or absence (ACE90-) of the 90 kDa ACE, the presence (FH+) or absence (FH-) of family history of hypertension, and the presence or absence of these two variables FH+/ACE90+ and FH-/ACE90-. We found an impaired endothelial dilatation in subjects who presented the 90 kDa N-domain ACE as follows: 11.4% +/- 5.3% in ACE90+ compared with 17.6% +/- 7.1% in ACE90- group and 12.4% +/- 5.6% in FH+/ACE90+ compared with 17.7% +/- 6.2% in FH-/ACE90- group, P < 0.05. Hcy and CRP levels were statistically significantly lower in FH+/ACE90+ than in FH-/ACE90- group, as follows: 10.0 +/- 2.3 mu M compared with 12.7 +/- 1.5 mu M, and 1.3 +/- 1.8 mg/L compared with 3.6 +/- 2.0 mg/L, respectively. A correlation between flow-mediated dilatation (FMD) and CRP, Hcy, and NOu levels was not found. Our study suggests a reduction in the basal NO production confirmed by NOu analysis in subjects with the 90 kDa N-domain ACE isoform alone or associated with a family history of hypertension, Our data suggest that the presence of the 90 kDa N-domain ACE itself may have a negative impact on flow-mediated dilatation stimulated by reactive hyperemia.
Idioma Inglês
Data 2008-07-01
Publicado em Molecular Medicine. Manhasset: Feinstein Inst Med Res, v. 14, n. 7-8, p. 429-435, 2008.
ISSN 1076-1551 (Sherpa/Romeo, fator de impacto)
Editor Feinstein Inst Med Res
Extensão 429-435
Fonte http://dx.doi.org/10.2119/2007-00112.Fernandes
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000257727000009
URI http://repositorio.unifesp.br/handle/11600/30750

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