Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment

Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment

Autor Tomiyama, Cristianne Autor UNIFESP Google Scholar
Carvalho, Aluizio B. Autor UNIFESP Google Scholar
Higa, Andrea Autor UNIFESP Google Scholar
Jorgetti, Vanda Google Scholar
Draibe, Sergio A. Autor UNIFESP Google Scholar
Canziani, Maria Eugenia F. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Vascular calcification is a strong prognostic marker of mortality in hemodialysis patients and has been associated with bone metabolism disorders in this population. in earlier stages of chronic kidney disease (CKD), vascular calcification also has been documented. This study evaluated the association between coronary artery calcification (CAC) and bone histomorphometric parameters in CKD predialysis patients assessed by multislice coronary tomography and by undecalcified bone biopsy. CAC was detected in 33 (66%) patients, and their median calcium score was 89.7 (0.4-2299.3 AU). the most frequent bone histologic alterations observed included low trabecular bone volume, increased eroded and osteoclast surfaces, and low bone-formation rate (BFR/BS). Multiple logistic regression analysis, adjusted for age, sex, and diabetes, showed that BFR/BS was independently associated with the presence of coronary calcification [p=.009; odd ratio (OR) = 0.15; 95% confidence interval (Cl) 0.036-0.619] This study showed a high prevalence of CAC in asymptomatic predialysis CKD patients. Also, there was an independent association of low bone formation and CAC in this population. in conclusion, our results provide evidence that low bone-formation rate constitutes another nontraditional risk factor for cardiovascular disease in CKD patients. 2010 American Society for Bone and Mineral Research.
Assunto CHRONIC KIDNEY DISEASE
PREDIALYSIS
CORONARY CALCIFICATION
BONE MINERAL METABOLISM
BONE-FORMATION RATE
Idioma Inglês
Data 2010-03-01
Publicado em Journal of Bone and Mineral Research. Hoboken: John Wiley & Sons Inc, v. 25, n. 3, p. 499-504, 2010.
ISSN 0884-0431 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 499-504
Fonte http://dx.doi.org/10.1359/jbmr.090735
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000276767700010
URI http://repositorio.unifesp.br/handle/11600/32302

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