Altered Balance of gamma-Aminobutyric Acidergic and Glutamatergic Afferent Inputs in Rostral Ventrolateral Medulla-Projecting Neurons in the Paraventricular Nucleus of the Hypothalamus of Renovascular Hypertensive Rats

Altered Balance of gamma-Aminobutyric Acidergic and Glutamatergic Afferent Inputs in Rostral Ventrolateral Medulla-Projecting Neurons in the Paraventricular Nucleus of the Hypothalamus of Renovascular Hypertensive Rats

Autor Biancardi, Vinicia Campana Google Scholar
Campos, Ruy Ribeiro Autor UNIFESP Google Scholar
Stern, Javier Eduardo Google Scholar
Instituição Med Coll Georgia
Universidade Federal de São Paulo (UNIFESP)
Resumo An imbalance of excitatory and inhibitory functions has been shown to contribute to numerous pathological disorders. Accumulating evidence supports the idea that a change in hypothalamic gamma-aminobutyric acid (GABA)-ergic inhibitory and glutamatergic excitatory synaptic functions contributes to exacerbated neurohumoral drive in prevalent cardiovascular disorders, including hypertension. However, the precise underlying mechanisms and neuronal substrates are still not fully elucidated in the present study, we combined quantitative immunohistochemistry with neuronal tract tracing to determine whether plastic remodeling of afferent GABAergic and glutamatergic inputs into identified RVLM-projecting neurons of the hypothalamic paraventricular nucleus (PVN-RVLM) contributes to an imbalanced excitatory/inhibitory function in renovascular hypertensive rats (RVH). Our results indicate that both GABAergic and glutamatergic innervation densities increased in oxytocin-positive, PVN-RVLM (OT-PVN-RVLM) neurons in RVH rats. Despite this concomitant increase, time-dependent and compartment-specific differences in the reorganization of these inputs resulted in an altered balance of excitatory/inhibitory inputs in somatic and dendritic compartments. A net predominance of excitatory over inhibitory inputs was found in OT-PVN-RVLM proximal dendrites. Our results indicate that, along with previously described changes in neurotransmitter release probability and postsynaptic receptor function, remodeling of GABAergic and glutamatergic afferent inputs contributes as an underlying mechanism to the altered excitatory/inhibitory balance in the PVN of hypertensive rats. J. Comp. Neurol. 518:567-585, 2010. (C) 2009 Wiley-Liss, Inc
Assunto synaptic
sympathetic
plasticity
brainstem
immunohistochemistry
hypertension
Idioma Inglês
Financiador National Institutes of Health
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Número do financiamento National Institutes of Health: R01HL68725
CAPES: BEX0325/03-1
Data 2010-03-01
Publicado em Journal of Comparative Neurology. Hoboken: Wiley-liss, v. 518, n. 5, p. 567-585, 2010.
ISSN 0021-9967 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 567-585
Fonte http://dx.doi.org/10.1002/cne.22256
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000273620800001
URI http://repositorio.unifesp.br/handle/11600/32311

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