Sleep and epilepsy: Exploring an intriguing relationship with a translational approach

Sleep and epilepsy: Exploring an intriguing relationship with a translational approach

Autor Matos, Gabriela Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Cavalheiro, Esper A. Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The relationship between sleep and epilepsy has been well established. There is a high prevalence of sleep disturbances in epilepsy, which are associated with a decreased quality of life of individuals with epilepsy. in view of this fact, preclinical research is necessary to address many gaps in knowledge. for instance, it is well known that sleep deprivation can trigger seizures; however, this is a complex pathophysiological event. in this context, there are many valuable animal models of epilepsy that reproduce clinical symptoms and can be used. Investigations using animal models that simulate clinical epilepsy are imperative. Furthermore, preclinical studies that reveal mechanisms related to sleep-epilepsy interactions are very important. Results of such studies can, in turn, improve the understanding of epilepsy itself and can be useful in developing new antiepileptic drugs and preventive measures to control seizures. Preclinical research should be performed using a translational framework with experimental designs that can lead to advances in the quality of life of individuals with epilepsy. in view of the fact that more than 50 million of people are affected by epilepsy around the world, understanding the relationship between sleep and epilepsy is imperative.This article is part of a Special Issue entitled the Future of Translational Epilepsy Research. (c) 2012 Elsevier Inc. All rights reserved.
Assunto Sleep
Sleep disturbance
Epilepsy
Preclinical research
Rodents
Idioma Inglês
Financiador Associacao Fundo de Incentivo a Pesquisa
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 10/15110-8
FAPESP: 12/05396-7
Data 2013-03-01
Publicado em Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 26, n. 3, p. 405-409, 2013.
ISSN 1525-5050 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 405-409
Fonte http://dx.doi.org/10.1016/j.yebeh.2012.12.003
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000316663900025
URI http://repositorio.unifesp.br/handle/11600/36040

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