Interleukin-6-174 G/C promoter gene polymorphism in nasal polyposis and asthma

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dc.contributor.author Kosugi, Eduardo Macoto [UNIFESP]
dc.contributor.author De Camargo-Kosugi, Cintia Meirelles [UNIFESP]
dc.contributor.author Hirai, Elcio Roldan [UNIFESP]
dc.contributor.author Mendes Neto, José Arruda [UNIFESP]
dc.contributor.author Gregario, Luis Carlos [UNIFESP]
dc.contributor.author Cotrim Guerreiro-Da-Silva, Ismael Dale [UNIFESP]
dc.contributor.author Weckx, Luc Louis Maurice [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:23Z
dc.date.available 2016-01-24T14:31:23Z
dc.date.issued 2013-03-01
dc.identifier http://www.rhinologyjournal.com/Abstract.php?id=1135
dc.identifier.citation Rhinology. Utrecht: Int Rhinologic Soc, v. 51, n. 1, p. 70-76, 2013.
dc.identifier.issn 0300-0729
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36075
dc.description.abstract Background: Interleukin-6 (IL-6) is an inflammatory mediator linked to nasal polyposis and asthma, with a single nucleotide polymorphism - 174 G/C that seems to promote an inflammatory status. We aimed to analyze the relationship between this polymorphism and asthmatic nasal polyposis patients.Methodology: Cross-sectional study to investigate IL-6 - 174 G/C genotypes of 45 nasal polyposis with asthma patients, 63 nasal polyposis-only patients, 45 asthma-only patients and 81 subjects without both diseases. Aspirin intolerance and atopy were main exclusion criteria. IL-6 genotyping was performed using the PCR method with specific primers followed by restriction enzyme analysis, classifying patients in GG, GC or CC genotype.Results: the GG genotype was the most frequent in all inflammatory groups. Less than 40% of controls presented with the GG genotype. There were significant differences between inflammatory groups and control group. No significant differences were seen when comparing inflammatory groups to each other, other than between nasal polyposis-only group and asthma-only group.Conclusion: the IL-6 74 GG genotype was found more frequently in all inflammatory groups than in controls. This genotype could influence nasal polyposis and asthma, and seems to be more important in the latter. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 70-76
dc.language.iso eng
dc.publisher Int Rhinologic Soc
dc.relation.ispartof Rhinology
dc.rights Acesso restrito
dc.subject asthma en
dc.subject nasal polyps en
dc.subject genetic polymorphism en
dc.subject interleukin-6 en
dc.subject single nucleotide polymorphism en
dc.title Interleukin-6-174 G/C promoter gene polymorphism in nasal polyposis and asthma en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Otorhinolaryngol Head & Neck Surg, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Gynecol, Lab Mol Gynecol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Otorhinolaryngol Head & Neck Surg, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Gynecol, Lab Mol Gynecol, São Paulo, Brazil
dc.identifier.doi 10.4193/Rhino12.166
dc.description.source Web of Science
dc.identifier.wos WOS:000332267600011



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