Low-level laser therapy (LLLT) (660 nm) alters gene expression during muscle healing in rats

Low-level laser therapy (LLLT) (660 nm) alters gene expression during muscle healing in rats

Autor Rodrigues, Natalia Camargo Google Scholar
Brunelli, Roberta Google Scholar
Selistre de Araujo, Heloisa Sobreiro Google Scholar
Parizotto, Nivaldo Antonio Google Scholar
Muniz Renno, Ana Claudia Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Carlos (UFSCar)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Introduction: the effects of LLLT were studied during muscle regeneration through gene expression.Methods: It was evaluated 10 and 50 J/cm(2) doses during 7, 14 and 21 days post cryoinjury, through histopathological analysis and mRNA MyoD, Myogenin, Vegf and Cox-2 expression.Results: Irradiated groups presented less inflammatory process than control group after 14 and 21 days. Cox-2 levels were downregulated in all irradiated groups after 7, 14 and 21 days. On day 7, both treated groups had a downregulation of Vegf levels, and an upregulation after 14 and 21 days, mainly with 50 J/cm(2). the MyoD levels were upregulated with high dose in all periods and with low dose after 21 days. Myogenin expression was downregulated in both treated groups after 7 days, and was upregulated with 10 J/cm(2) after 21 days.Conclusion: These responses suggest that LLLT can improve the skeletal muscle regeneration through the gene expression stimulation. (C) 2013 Elsevier B.V. All rights reserved.
Assunto Low-level laser therapy
Rat
Muscle repair
Genes expression
MRFs
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data 2013-03-05
Publicado em Journal of Photochemistry and Photobiology B-biology. Lausanne: Elsevier Science Sa, v. 120, p. 29-35, 2013.
ISSN 1011-1344 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 29-35
Fonte http://dx.doi.org/10.1016/j.jphotobiol.2013.01.002
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000317882100004
URI http://repositorio.unifesp.br/handle/11600/36077

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