Autor |
Sartori, Adriano
![]() ![]() Mano, Camila M. ![]() Mantovani, Mariana C. ![]() ![]() Dyszy, Fabio H. ![]() Massari, Julio ![]() Tokikawa, Rita ![]() Nascimento, Otaciro R. ![]() Nantes, Iseli L. ![]() Bechara, Etelvino José Henriques ![]() ![]() |
Instituição | Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Universidade Federal do ABC (UFABC) |
Resumo | Age-related diseases are associated with increased production of reactive oxygen and carbonyl species such as methylglyoxal. Aminoacetone, a putative threonine catabolite, is reportedly known to undergo metal-catalyzed oxidation to methylglyoxal, NH4+ ion, and H2O2 coupled with (i) permeabilization of rat liver mitochondria, and (ii) apoptosis of insulin-producing cells. Oxidation of aminoacetone to methylglyoxal is now shown to be accelerated by ferricytochrome c, a reaction initiated by one-electron reduction of ferricytochrome c by aminoacetone without amino acid modifications. the participation of O-2(center dot-) and HO center dot radical intermediates is demonstrated by the inhibitory effect of added superoxide dismutase and Electron Paramagnetic Resonance spin-trapping experiments with 5,5'-dimethyl-1-pyrroline-N-oxide. We hypothesize that two consecutive one-electron transfers from aminoacetone (E-0 values = -0.51 and -1.0 V) to ferricytochrome c (E-0 = 0.26 V) may lead to aminoacetone enoyl radical and, subsequently, imine aminoacetone, whose hydrolysis yields methylglyoxal and NH4+ ion. in the presence of oxygen, aminoacetone enoyl and O-2(center dot-) radicals propagate aminoacetone oxidation to methylglyoxal and H2O2. These data endorse the hypothesis that aminoacetone, putatively accumulated in diabetes, may directly reduce ferricyt c yielding methylglyoxal and free radicals, thereby triggering redox imbalance and adverse mitochondrial responses. |
Idioma | Inglês |
Financiador |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) INCT Processos Redox em Biomedicina (Brazil) |
Data | 2013-03-06 |
Publicado em | Plos One. San Francisco: Public Library Science, v. 8, n. 3, 13 p., 2013. |
ISSN | 1932-6203 (Sherpa/Romeo, fator de impacto) |
Editor | Public Library Science |
Extensão | 13 |
Fonte |
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Direito de acesso | Acesso aberto ![]() |
Tipo | Artigo |
Web of Science | WOS:000316936100046 |
URI | http://repositorio.unifesp.br/handle/11600/36080 |
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