Structural and Photophysical Properties of Peptide Micro/Nanotubes Functionalized with Hypericin

Structural and Photophysical Properties of Peptide Micro/Nanotubes Functionalized with Hypericin

Autor Souza, Marcia I. Google Scholar
Jaques, Ygor M. Google Scholar
Andrade, Gislaine P. de Google Scholar
Ribeiro, Anderson O. Google Scholar
Silva, Emerson R. da Google Scholar
Fileti, Eudes E. Autor UNIFESP Google Scholar
Avilla, Erick de Souza Google Scholar
Pinheiro, Mauricio V. B. Google Scholar
Krambrock, Klaus Google Scholar
Alves, Wendel A. Google Scholar
Instituição Universidade Federal do ABC (UFABC)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Minas Gerais (UFMG)
Resumo Hypericin is a photosensitizer with promising applications in photodynamic therapy (PDT) for cancer and infectious diseases treatments. Herein, we present a basic research study of L-diphenylalanine micro/nanotubes (FF-NTs) functionalized with hypericin. the system has special properties according to the hypericin concentration, with direct consequences on both morphological and photophysical behaviors. A clear dependence between the size of the tubes and the concentration of hypericin is revealed. the generation of reactive oxygen species (ROS) is found to be improved by similar to 57% in the presence of FF-NTs, as indirectly measured from the absorbance profile of 1,3-diphenylisobenzofuran (DPBF). in addition, when hypericin appears conjugated with FF-NTs, the characteristic fluorescence lifetime is significantly boosted, demonstrating the role of FF-NTs to enhance the photophysical properties and stabilizing the fluorophore in excited states. Electron paramagnetic resonance allows the proposition of a mechanism for the generation of ROS. Molecular dynamics simulations bring new insights into the interaction between hypericin and peptide assemblies, suggesting the spatial organization of the fluorophore onto the surface of the supramolecular structures as a key element to improve the photophysical properties reported here.
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 08/53576-9
FAPEMIG: APQ 02000-10
FAPESP: 08/57805-2
CNPq: 573672/2008-3
CNPq: 472197/2012-6
Data 2013-03-07
Publicado em Journal of Physical Chemistry B. Washington: Amer Chemical Soc, v. 117, n. 9, p. 2605-2614, 2013.
ISSN 1520-6106 (Sherpa/Romeo, fator de impacto)
Editor Amer Chemical Soc
Extensão 2605-2614
Fonte http://dx.doi.org/10.1021/jp3113655
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000315979600002
URI http://repositorio.unifesp.br/handle/11600/36082

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