European Ancestry Predominates in Neuromyelitis Optica and Multiple Sclerosis Patients from Brazil

European Ancestry Predominates in Neuromyelitis Optica and Multiple Sclerosis Patients from Brazil

Autor Brum, Doralina Guimaraes Google Scholar
Luizon, Marcelo Rizzatti Google Scholar
Santos, Antonio Carlos Google Scholar
Lana-Peixoto, Marco Aurelio Google Scholar
Rocha, Cristiane Franklin Google Scholar
Brito, Maria Lucia Google Scholar
Lobato de Oliveira, Enedina Maria Autor UNIFESP Google Scholar
Bichuetti, Denis Bernardi Autor UNIFESP Google Scholar
Gabbai, Alberto Alan Autor UNIFESP Google Scholar
Diniz, Denise Sisterolli Google Scholar
Kaimen-Maciel, Damacio Ramon Google Scholar
Comini-Frota, Elizabeth Regina Google Scholar
Vieira Wiezel, Claudia E. Google Scholar
Netto Muniz, Yara Costa Google Scholar
Silva Costa, Roberta Martins da Google Scholar
Mendes-Junior, Celso Teixeira Google Scholar
Donadi, Eduardo Antonio Google Scholar
Barreira, Amilton Antunes Google Scholar
Simoes, Aguinaldo Luiz Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de Minas Gerais (UFMG)
Hosp Restauracao
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Goiás (UFG)
Universidade Estadual de Londrina (UEL)
Resumo Background: Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients.Methods: Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirao Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirao Preto (NMO-RP).Principal Findings: European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. in contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population.Conclusions: Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil.
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundacao de Apoio ao Ensino, Pesquisa e Assisteancia do HCFMRP-USP (FAEPA-Brazil)
Data 2013-03-20
Publicado em Plos One. San Francisco: Public Library Science, v. 8, n. 3, 5 p., 2013.
ISSN 1932-6203 (Sherpa/Romeo, fator de impacto)
Editor Public Library Science
Extensão 5
Fonte http://dx.doi.org/10.1371/journal.pone.0058925
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000317562600045
URI http://repositorio.unifesp.br/handle/11600/36094

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