Monitoring for HHV-6 Infection After Renal Transplantation: Evaluation of Risk Factors for Sustained Viral Replication

Monitoring for HHV-6 Infection After Renal Transplantation: Evaluation of Risk Factors for Sustained Viral Replication

Autor Luiz, Claudia R. Autor UNIFESP Google Scholar
Machado, Clarisse M. Google Scholar
Canto, Cynthia L. M. Google Scholar
Christ, Silvia C. C. Autor UNIFESP Google Scholar
Pestana, Jose O. M. Autor UNIFESP Google Scholar
Kotton, Camille N. Google Scholar
Camargo, Luis F. A. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Massachusetts Gen Hosp
Resumo Background. Human herpesvirus-6 (HHV-6) is known to reactivate after renal transplantation and has been associated with several clinical manifestations. Risk factors for sustained viral replication, however, remain unclear.Methods. Thirty consecutive kidney transplant patients were prospectively followed for HHV-6 replication between February 2007 and February 2008. Plasma samples for DNA detection were collected from the donor and the recipient before transplantation and from the recipient weekly for the first 2 months after transplantation and then every 2 weeks for 2 additional months. HHV-6 active infection was defined as detection of viral DNA in plasma, by polymerase chain reaction, in at least two consecutive samples over an interval of at least 1 week.Results. Active viral infection was detected in 25% of the recipients before transplantation and 27% (8 of 30) of the patients after transplantation. the mean time to onset of viral replication was 28.1 days after transplantation and 7 of 8 (87.5%) were asymptomatic. Risk factors associated with active HHV-6 infection were receiving an organ from a living donor (P=0.028), recipients with IgM antibodies detected before transplantation (P=0.005), and pretransplantation recipient HHV-6 viral load more than 10,000 copies/mL plasma (P=0.034).Conclusions. Active HHV-6 infection occurs early after renal transplantation and is mostly asymptomatic. Donor or recipient infection may occur at the time of transplantation and are related to higher rates of posttransplantation infections.
Assunto Human herpesvirus 6 (HHV-6)
Renal transplantation
PCR
Active viral infection
Sustained viral replication
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data 2013-03-27
Publicado em Transplantation. Philadelphia: Lippincott Williams & Wilkins, v. 95, n. 6, p. 842-846, 2013.
ISSN 0041-1337 (Sherpa/Romeo, fator de impacto)
Editor Lippincott Williams & Wilkins
Extensão 842-846
Fonte http://dx.doi.org/10.1097/TP.0b013e3182807ab7
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000316343000017
URI http://repositorio.unifesp.br/handle/11600/36103

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