Diffusion tensor imaging of the cervical spinal cord of patients with Neuromyelitis Optica

Diffusion tensor imaging of the cervical spinal cord of patients with Neuromyelitis Optica

Autor Rivero, Rene L. M. Autor UNIFESP Google Scholar
Oliveira, Enedina M. L. Autor UNIFESP Google Scholar
Bichuetti, Denis B. Autor UNIFESP Google Scholar
Gabbai, Alberto A. Autor UNIFESP Google Scholar
Nogueira, Roberto G. Autor UNIFESP Google Scholar
Abdala, Nitamar Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: Previous studies have demonstrated a correlation between Expanded Disability Status Scale (EDSS) and Diffusion Tensor Imaging (DTI) metrics, but the conclusions were based on evaluations of the entire cervical spinal cord.Objectives: the purpose of this study was to quantify the FA and MD values in the spinal cord of NMO patients, separating the lesion sites from the preserved sites, which has not been previously preformed. in addition, we attempted to identify a correlation with EDSS.Methods: DTI was performed in 11 NMO patients and 11 healthy individuals using a 1.5-T MRI scanner. We measured the FA and MD at ROIs positioned along the cervical spinal cord. the mean values of FA and MD at lesion, preserved and spinal cord sites were compared with those of a control group. We tested the correlations between the mean FA and MD with EDSS.Results: FA in NMO patients was significantly reduced in lesion sites (0.44 vs. 0.55, p = 0.0046), preserved sites (0.46 vs. 0.55, p = 0.0015), and all sites (0.45 vs 0.55, p = 0.0013) while MD increased only in lesion sites (1.03 x 10(-3) mm(2)/s vs. 0.90 x 10(-3) mm(2)/s, p = 0.009). the FA demonstrated the best correlation with EDSS (r = -0.7603, p = 0.0086), particularly at lesion sites.Conclusions: the results reinforce the importance of the FA index and confirm the hypothesis that NMO is a diffuse disease. (C) 2014 Elsevier Inc. All rights reserved.
Assunto Neuromyelitis optica
Diffusion tensor imaging
Spinal cord
Disability evaluation
Idioma Inglês
Financiador TEVA Pharmaceutical (Brazilian branch)
Data 2014-06-01
Publicado em Magnetic Resonance Imaging. New York: Elsevier B.V., v. 32, n. 5, p. 457-463, 2014.
ISSN 0730-725X (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 457-463
Fonte http://dx.doi.org/10.1016/j.mri.2014.01.023
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000335422800008
URI http://repositorio.unifesp.br/handle/11600/37835

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