Comparison of the effects of continuous positive airway pressure, oral appliance and exercise training in obstructive sleep apnea syndrome

Comparison of the effects of continuous positive airway pressure, oral appliance and exercise training in obstructive sleep apnea syndrome

Autor Schutz, Teresa Cristina Barros Autor UNIFESP Google Scholar
Cunha, Thays Crosara Abrahao Autor UNIFESP Google Scholar
Moura-Guimaraes, Thais Autor UNIFESP Google Scholar
Luz, Gabriela Pontes Autor UNIFESP Google Scholar
Ackel-D'elia, Carolina Autor UNIFESP Google Scholar
Alves, Eduardo da Silva Autor UNIFESP Google Scholar
Pantiga Junior, Gilberto Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Bittencourt, Lia Rita Azeredo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE: There are several treatments for obstructive sleep apnea syndrome, such as weight loss, use of an oral appliance and continuous positive airway pressure, that can be used to reduce the signs and symptoms of obstructive sleep apnea syndrome. Few studies have evaluated the effectiveness of a physical training program compared with other treatments. The aim of this study was to assess the effects of physical exercise on subjective and objective sleep parameters, quality of life and mood in obstructive sleep apnea patients and to compare these effects with the effects of continuous positive airway pressure and oral appliance treatments. METHODS: Male patients with moderate to severe obstructive sleep apnea and body mass indices less than 30 kg/m2 were randomly assigned to three groups: continuous positive airway pressure (n = 9), oral appliance (n = 9) and physical exercise (n = 7). Polysomnographic recordings, blood samples and daytime sleepiness measurements were obtained prior to and after two months of physical exercise or treatment with continuous positive airway pressure or an oral appliance. Clinicaltrials.gov: NCT01289392 RESULTS: After treatment with continuous positive airway pressure or an oral appliance, the patients presented with a significant reduction in the apnea-hypopnea index. We did not observe changes in the sleep parameters studied in the physical exercise group. However, this group presented reductions in the following parameters: T leukocytes, very-low-density lipoprotein and triglycerides. Two months of exercise training also had a positive impact on subjective daytime sleepiness. CONCLUSIONS: Our results suggest that isolated physical exercise training was able to modify only subjective daytime sleepiness and some blood measures. Continuous positive airway pressure and oral appliances modified the apnea-hypopnea index.
Assunto Obstructive Sleep Apnea
CPAP
OA
Exercise Training
Subjective Daytime Sleepiness
Polysomnography
Idioma Inglês
Financiador AFIP
CEPE
CEMSA
CNPq
FAPESP
Número do financiamento 2009/01031-1 e 98/14303-3
Data 2013-01-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 68, n. 8, p. 1168-1174, 2013.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
Editor Faculdade de Medicina / USP
Extensão 1168-1174
Fonte http://dx.doi.org/10.6061/clinics/2013(08)17
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000324496600017
SciELO S1807-59322013000801168 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/7573

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