Myeloid-derived suppressor cells and associated events in urethane-induced lung cancer

Myeloid-derived suppressor cells and associated events in urethane-induced lung cancer

Autor Teixeira, Daniela Autor UNIFESP Google Scholar
Almeida, Joaquim Soares de Autor UNIFESP Google Scholar
Visniauskas, Bruna Autor UNIFESP Google Scholar
Gomes, Guiomar Nascimento Autor UNIFESP Google Scholar
Hirata, Aparecida Emiko Autor UNIFESP Google Scholar
Bueno, Valquiria Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVES: Myeloid-derived suppressor cells contribute to the immunosuppressive microenvironment during tumor development and limit the efficacy of cancer immunotherapy. Identifying myeloid-derived suppressor cells and associated factors is the first step in creating strategies to reverse the suppressive effects of these cells on the immune system. METHODS: To induce lung cancer, we administered 2 doses of urethane to BALB/c mice and observed these animals for 120 days. After this period, we evaluated the percentage of myeloid-derived suppressor cells in the blood, lung and bone marrow. The expression of alpha-smooth muscle actin, transforming growth factor-β, Toll-like receptor 2, Toll-like receptor 4, and interleukin-6 was also determined in the lung tissue. RESULTS: Myeloid-derived suppressor cells were increased in all evaluated tissues after lung cancer development in association with increased Toll-like receptor 4 expression and decreased interleukin-6 expression in the lung. We observed alpha-smooth muscle actin and transforming growth factor-β expression in lung nodules. CONCLUSIONS: We believe that the early diagnosis of cancer through determining the blood levels of myeloid-derived suppressor cells followed by the depletion of these cells should be further investigated as a possible approach for cancer treatment.
Assunto Lung Cancer
Myeloid-Derived Suppressor Cells
Toll-Like Receptors
Cytokines
Fibroblasts
Idioma Inglês
Financiador Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP
Conselho Nacional de Pesquisa (CNPq)
Data 2013-06-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 68, n. 6, p. 858-864, 2013.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
Editor Faculdade de Medicina / USP
Extensão 858-864
Fonte http://dx.doi.org/10.6061/clinics/2013(06)22
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000320463800022
SciELO S1807-59322013000600858 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/7834

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