Autor |
Teixeira, Daniela
![]() ![]() Almeida, Joaquim Soares de ![]() ![]() Visniauskas, Bruna ![]() ![]() Gomes, Guiomar Nascimento ![]() ![]() Hirata, Aparecida Emiko ![]() ![]() Bueno, Valquiria ![]() ![]() |
Instituição | Universidade Federal de São Paulo (UNIFESP) |
Resumo | OBJECTIVES: Myeloid-derived suppressor cells contribute to the immunosuppressive microenvironment during tumor development and limit the efficacy of cancer immunotherapy. Identifying myeloid-derived suppressor cells and associated factors is the first step in creating strategies to reverse the suppressive effects of these cells on the immune system. METHODS: To induce lung cancer, we administered 2 doses of urethane to BALB/c mice and observed these animals for 120 days. After this period, we evaluated the percentage of myeloid-derived suppressor cells in the blood, lung and bone marrow. The expression of alpha-smooth muscle actin, transforming growth factor-β, Toll-like receptor 2, Toll-like receptor 4, and interleukin-6 was also determined in the lung tissue. RESULTS: Myeloid-derived suppressor cells were increased in all evaluated tissues after lung cancer development in association with increased Toll-like receptor 4 expression and decreased interleukin-6 expression in the lung. We observed alpha-smooth muscle actin and transforming growth factor-β expression in lung nodules. CONCLUSIONS: We believe that the early diagnosis of cancer through determining the blood levels of myeloid-derived suppressor cells followed by the depletion of these cells should be further investigated as a possible approach for cancer treatment. |
Assunto |
Lung Cancer
Myeloid-Derived Suppressor Cells Toll-Like Receptors Cytokines Fibroblasts |
Idioma | Inglês |
Financiador |
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP
Conselho Nacional de Pesquisa (CNPq) |
Data | 2013-06-01 |
Publicado em | Clinics. Faculdade de Medicina / USP, v. 68, n. 6, p. 858-864, 2013. |
ISSN | 1807-5932 (Sherpa/Romeo, fator de impacto) |
Editor | Faculdade de Medicina / USP |
Extensão | 858-864 |
Fonte |
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Direito de acesso | Acesso aberto ![]() |
Tipo | Artigo |
Web of Science | WOS:000320463800022 |
SciELO | S1807-59322013000600858 (estatísticas na SciELO) |
URI | http://repositorio.unifesp.br/handle/11600/7834 |
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