Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity

Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity

Autor Toma, Walber Google Scholar
Guimarães, Luciana Lopes Autor UNIFESP Google Scholar
Brito, Alba R.m.s. Google Scholar
Santos, Aldo R. Google Scholar
Cortez, Fernando S. Google Scholar
Pusceddu, Fábio H. Google Scholar
Cesar, Augusto Autor UNIFESP Google Scholar
Silveira Junior, Landulfo Google Scholar
Pacheco, Marcos T.t. Google Scholar
Pereira, Camilo Dias Seabra Autor UNIFESP Google Scholar
Instituição Universidade Santa Cecília Programa de Pós-graduação em Sustentabilidade de Ecossistemas Costeiros e Marinhos Laboratório de Pesquisa em Produtos Naturais
Universidade Estadual de Campinas (UNICAMP)
Universidade Santa Cecília Laboratório de Ecotoxicologia
Universidade Federal de São Paulo (UNIFESP)
Universidade Camilo Castelo Branco Instituto de Engenharia Biomédica
Resumo Gastric ulcers are a significant medical problem and the development of complications lead to significant mortality rates worldwide. In Brazil, Carthamus tinctorius L., Asteraceae, seeds essential oil, the safflower oil, is currently used as a thermogenic compound and as treatment for problems related to the cardiovascular system. In this study, by Raman spectroscopy, it was shown that oleic and linoleic acids are the compounds present in higher concentrations in the safflower oil. We demonstrated that safflower oil (750 mg/kg, p.o.) decrease the ulcerogenic lesions in mice after the administration of hydrochloric acid-ethanol. The gastric ulcers induced by non-steroidal anti-inflammatory drug (NSAID) in mice treated with cholinomimetics were treated with four different doses of safflower oil, of which, the dose of 187.5 mg/kg (p.o.) showed significant antiulcerogenic properties (**p < 0.01). Moreover, the safflower oil at doses of 187.5 mg/kg (i.d.) increased the pH levels, gastric volume (**p < 0.01) and gastric mucus production (***p < 0.001), and decreased the total gastric acid secretion (***p < 0.001). The acute toxicity tests showed that safflower oil (5.000 mg/kg, p.o.) had no effect on mortality or any other physiological parameter. Ecotoxicological tests performed using Daphnia similis showed an EC50 at 223.17 mg/l, and therefore safflower oil can be considered “non-toxic” based on the directive 93/67/EEC on risk assessment for new notified substances by European legislation. These results indicate that the antiulcer activity of Safflower oil may be due to cytoprotective effects, which serve as support for new scientific studies related to this pathology.
Assunto Antiulcerogenic activity
Ecotoxicology
Raman spectroscopy
Safflower oil
Toxicology
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 2009/01788-5
Data 2014-10-01
Publicado em Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 24, n. 5, p. 538-544, 2014.
ISSN 0102-695X (Sherpa/Romeo, fator de impacto)
Editor Sociedade Brasileira de Farmacognosia
Extensão 538-544
Fonte http://dx.doi.org/10.1016/j.bjp.2014.09.004
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000346075000006
SciELO S0102-695X2014000500538 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/8644

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